Unravelling Antigenic Cross-Reactions toward the World of Coronaviruses: Extent of the Stability of Shared Epitopes and SARS-CoV-2 Anti-Spike Cross-Neutralizing Antibodies

The human immune repertoire retains the molecular memory of a very great diversity of target antigens (epitopes) and can recall this upon a second encounter with epitopes against which it has previously been primed.Although genetically diverse, proteins of coronaviruses exhibit sufficient conservation to lead to antigenic cross-reactions.In this re

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Black Holes and Wormholes in Extended Gravity

We discuss black hole type solutions and wormhole type ones in the effective gravity models.Such models appear during the attempts to construct the quantum theory of gravity.The INCENSE PATCHOULI mentioned solutions, being, mostly, the perturbative generalisations of well-known ones in general relativity, carry out additional set of parameters and,

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The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

Our ability to discover effective drug combinations is limited, in part by insufficient understanding of how the transcriptional response of two monotherapies results in that of their combination.We analyzed matched time course RNAseq profiling of cells treated with single drugs and their combinations and found Play Mats that the transcriptional si

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